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莫日根

时间:2021-01-10    作者:

  

      莫日根(Morigen),1984年7月毕业于内蒙古大学植物学专业,获学士学位;2005年3月毕业于挪威奥斯陆大学分子生物学专业,获博士学位;2005年4月至2009年9月在挪威肿瘤医院癌症研究所做博士后研究。2009年10月回国任内蒙古大学生命科学学院生物化学与分子生物学教授、博士生导师,2010年10月至2020年3月任生命科学学院副院长、院长,提出“立足草畜、旁及医药、创建一流”的办学方针。

学术任职:中国生物化学与分子生物学会理事、《中国生物化学与分子生物学报》和《生命的化学》编委、内蒙古生物化学与分子生物学会理事长。曾任中国细胞生物学会第10、11和12届理事、《中国细胞生物学学报》第2届编委会副主编、《Frontiers in Microbiology》Topic Editor。创建内蒙古自治区细胞分子调控重点实验室和内蒙古自治区细胞分子工程技术研究中心,现任名誉主任

科学研究:研究细菌和肿瘤细胞基因组稳定与演化机制,重点探讨大肠杆菌DNA复制与基因组稳定、细胞周期、代谢和基因表达调控以及环境适应和耐药分子机理。主持国家自然科学基金项目6项、内蒙古自然科学基金重大和重点项目各1项、内蒙古科技计划项目2项、内蒙古党委组织部草原英才及其滚动支持项目各1项,内蒙古高等学校细胞的分子调控创新团队发展计划1项。发表论文70余篇;主编电子书《Bacterial Transcription Factors and the Cell Cycle》1本

发现并揭示复制起始蛋白DnaA依赖的转录衰减新型核糖开关(见下图);揭示DnaA对DNA复制和损伤、细胞分裂、基因表达的调控机制;发现天冬氨酸代谢对细胞周期的协同作用;首次揭示基因表达的空间调控新模式

教育教学:主持国家级一流课程-《分子生物学》、负责内蒙古自治区生物化学系列课程教学团队。创建并实践“生命科学多维度立体化创新人才培养模式”, 架构研究型创新实验课程体系,实践科学史和问题导向的教学方法,提出了一系列独到见解和看法,发表教学研究论文20篇。获内蒙古自治区高等教育教学成果一等奖2项、三等奖2项。到2025年培养博士18名、全日制硕士40名、指导本科毕业论文48篇。


Emailmorigenm@imu.edu.cn


Research interests:

1. The Escherichia coli DNA replication, cell cycle and environmental adaptation.

2. DNA replication in cancer cells.


相关SCI论文(eBook

45. Qiao J,Zhu W,Du D,Morigen. Characterizing common factors affecting replication initiation during H2O2 exposure and genetic mutation-induced oxidative stress in Escherichia coli, Int J Mol Sci, 2025, 26, 2968. https://doi.org/10.3390/ ijms26072968.

44. Qiao J, Du D, Wang Y, Xi L, Zhu W*, Morigen*. Uncovering the effects of non-lethal oxidative stress on replication initiation in Escherichia coli, Gene, 2025, 933 (2025) 148992. doi: 10.1016/j.gene.2024.148992.

43. Zhao H, Zhang L, Du D, Mai L, Liu Y, Morigen*, Fan L*. The RIG-I-like receptor signaling pathway triggered by Staphylococcus aureus promotes breast cancer metastasis, Int Immunopharmacol, 2024, 142 (2024) 113195.

42. Jiao J, Lv X, Shen C, Morigen*. Genome and transcriptomic analysis of the adaptation of Escherichia coli to environmental stresses, Computational and Structural Biotechnology Journal, 2024, 23 (2024) 2132–2140, doi.org/10.1016/j.csbj.2024.05.033.

41. Shen C, Morigen*. Mechanism of transcription-translation coupling in Escherichia coli, Prog Biochem Biophys, 2024, 51(3):15~524.

40. Morigen*, Glinkowska M, Xie J*, Priyadarshini R and Kasho K. Editorial: Bacterial transcription factors and the cell cycle, volume II, Front Microbiol, 2023, 14:1252924. doi: 10.3389/fmicb.2023.1252924.

39. Zhu W, Xi L, Qiao J, Du D, Wang Y, Morigen*. Involvement of OxyR and Dps in the repression of replication initiation by DsrA small RNA in Escherichia coli, Gene, 2023, 21:147659. doi: 10.1016/j.gene.2023.147659.

38. Yao Y, Sun H, Wurihan, Gegeheng, Gezi G, Skarstad K*, Fan L*, Morigen*. A DnaA-dependent riboswitch for transcription attenuation of the his operon, mLife, 2023, 2(2):126-140.

37. Zhao H, Jia P, Nanding K, Wu M, Bai X, Morigen M, L Fan*. Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-AThr288-geminin dual signaling pathways, Front Pharmacol. 2022 Dec 19;13:1046269. doi: 10.3389/fphar.2022.1046269.

36. Tian X, Nanding K, Dai X, Wang Q, Wang J, Morigen*, L Fan*. Pattern recognition receptor mediated innate immune response requires a Rif-dependent pathwayJ Autoimmunity, 2022, 134 (2023) 102975.

35. Tian X, Lu J, Nanding K, Zhang L, Liu Y, Mailisu, Morigen and L Fan*. The antihyperlipidemic drug potassium piperonate impairs the migration and tumorigenesis of breast cancer cells via the upregulation of miR-31, Front Oncol, 2022, DOI 10.3389/fonc.2022.828160.

34. Lv X, Zhang R, Wang J, Morigen*. The absence of CsdA in Escherichia coli increases DNA replication and cell size but decreases growth rate at low temperature, BBRC, 2022, 631 (2022) 41-47.

33. Qiao J, Liang Y, Wang Y, Morigen*. Trimethylamine N-Oxide Reduces the Susceptibility of Escherichia coli to Multiple Antibiotics, Front Microbiol, 2022, 13:956673.doi:10.3389/fmicb.2022.956673.

32. Li G, Morigen, Y Yao*. TorR/TorS Two-Component system resists extreme acid environment by regulating the key response factor RpoS in Escherichia coliGene2022821 (2022) 146295.

31. Morigen, Glinkowska M, J Xie. E-book: eds. Bacterial Transcription Factors and the Cell Cycle, Lausanne: Frontiers Media SA. 2022, doi: 10.3389/978-2-88974-324-7. ISBN 978-2-88974-324-7.

30. Morigen*, Glinkowska M, J Xie. Editorial: bacterial transcription factors and the cell cycle, Front Microbiol, 2021, 12:821394.doi: 10.3389/fmicb.2021.821394.

29.Wang F, Yang Y, Morigen*. RNA polymerase-surveilled mechanisms for DNA repair, Prog Biochem Biophys, 2021, 48(11)1260~1272.

28. GeZi G, Liu R, Du D, Wu N, Bao N, Fan L, Morigen*. YfiF, an unknown protein, affects initiation timing of chromosome replication in Escherichia coli, J Basic Microbiol, 2021, 61(10):883-899.doi: 10.1002/jobm.202100265.

27. Zhao H, Gezi G, Tian X, Jia P, Morigen, L Fan*. Lysophosphatidic acid-induced EGFR transactivation promotes gastric cancer cell DNA replication by stabilizing Geminin in the S phaseFront Pharmacol, 2021, 12:706240doi: 10.3389/fphar.2021.706240.

26. Wu D, Baigalmaa L, Yao Y, Li G, Su M*, Fan L*, Morigen*. The Escherichia coli QseB/QseC signaling is required for correct timing of replication initiation and cell motility, Gene, 2021, 773 (2021) 145374.

25. Ma Q, Morigen*. TERRA-mediated telomere maintenance, Prog Biochem Biophys, 2021, 48(5)529-540.

24. Dong Q, Qiao J, Sun H, Fan L, Morigen*. The replication transcription collision-based mutations and evolutionary implications, Prog Biochem Biophys, 2020, 47(11): 1162-1173.

23.Huang T, Yuan H, Fan L, Morigen*. H-NS, IHF, and DnaA lead to changes in nucleoid organizations, replication initiation, and cell division, J Basic Microbiol, 2020, DOI: 10.1002/jobm.201900497, 60:136-148.

22. Wurihan, Gezi, Brambilla E, Wang S, Sun H, Fan L, Shi Y1, Sclavi B*, Morigen*. DnaA and LexA proteins regulate transcription of the uvrB gene in Escherichia coli: the role of DnaA in the control of the SOS regulon, Front Microbiol, 2018, 9:1212, https://doi.org/10.3389/fmicb.2018.01212.

21. Yao Y, Enkhtsetseg S, Odsbu I, Fan L, Morigen*. Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1–1 plasmid, BMC Microbiol, 2018, 18:27 https://doi.org/10.1186/s12866-018-1162-3.

20. Zhang S, Wunier, Yao Y, Morigen*. Defects in ribosome function delay the initiation of chromosome replication in Escherichia coli, J Basic Microbiol, 2018, doi: 10.1002/jobm.201800295, 58:1091-1099.

19. Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen*. The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis, Oncotarget, 2017, doi:10.18632/oncotarget.16872.

18. Yao Y, Fan L, Shi Y, Odsbu I, Morigen*. A spatial control for correct timing of gene expression during the Escherichia coli cell cycle, Genes, 2017, 8(1), 1: doi:10.3390/genes8010001.

17. Wurihan, Wunier, Li H, Fan L, Morigen*. Trans-translation ensures timely initiation of DNA replication and DnaA synthesis in Escherichia coli, Gent Mol Res, 2016, 15 (3): gmr.15038407.

16. Yao Y, Wunier, Morigen*. Absence of the BaeR protein leads to the early initiation of DNA replication in Escherichia coli, Gent Mol Res, 2015, 14(4):16888-16895.

15. Fan L, Yan H, Pellegrin S, Morigen*, H Mellor*. The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction, Neurosci Lett, 2015, 590(-):178-183.

14. Dong Q, Dong A*, Morigen*. Evaluation of novel antibacterial N-halamine nanoparticles prodrugs towards susceptibility of Escherichia coli induced by DksA protein, Molecules, 2015, 21;20(4):7292-308.

13. Liu F, Qimuge, Hao J, Yan H, Bach T, Fan L*, Morigen*. AspC-mediated aspartate metabolism coordinates the Escherichia coli cell cycle, PLoS ONE, 2014, 9(3):e92229.

12. Morigen, Flatten I, K Skarstad*. The Escherichia coli datA site promotes proper regulation of cell division, SGM-Microbiol, 2014, 160(4):703-710.

11. Johnsen L, Flåtten I, Morigen, Dalhus B, Bjørås M, Waldminghaus T, K Skarstad*. The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of Replication, Mol Microbiol , 2011, 79(2):433-446.

10.Weatherspoon-Griffin N, Zhao G, Kong W, Kong Y, Morigen, Andrews-Polymenis H, McClelland M, Y Shi*. The CpxR/CpxA two-component system up-regulates two Tat-dependent peptidoglycan amidases to confer bacterial resistance to antimicrobial peptide, J Biol Chem, 2011, 286(7):5529-39.

9. Morigen, Odsbu I, K Skarstad*. Growth rate dependent numbers of SeqA structures organize the multiple replication forks in rapidly growing Escherichia coli, Genes Cells, 2009, 14(5):643-657.

8. Wang J*, Morigen. BayesPI--a new model to study protein-DNA interaction: a case study of condition-specific protein binding parameters for yeast transcription factors, BMC Bioinformatics, 2009, 10:345.

7. Odsbu I, Morigen, K Skarstad*. A reduction in ribonucleotide reductase activity slows down the chromosome replication fork but does not change its localization, PLoS ONE, 2009, 4(10):e7617.

6. Flåtten I, Morigen, K Skarstad*. DnaA protein interacts with RNA polymerase and protects it from the effect of rifampicin, Mol Microbiol, 71(4):1018-1030, 2009.

5. Bach T, Morigen, K Skarstad*. The initiator protein DnaA contributes to keeping new origins inactivated by promoting the presence of hemimethylated DNA, J Mol Biol, 2008, 384(5):1076-85.

4. Morigen, Molina F, K Skarstad*. Deletion of the datA site does not affect once-per-cell-cycle timing but induces rifampin-resistant replication, J Bacteriol, 2005, 187(12):3913-20.

3. Morigen, Løbner-Olesen A, K Skarstad*. Titration of the Escherichia coli DnaA protein to excess datA sites causes destabilization of replication forks, delayed replication initiation and delayed cell division, Mol Microbiol, 50:349-362, 2003.

2. Morigen, Boye E, Skarstad K, A Løbner-Olesen*. Regulation of chromosomal replication by DnaA protein availability in Escherichia coli: effects of the datA region, Biochim Biophys Acta, 2001, 1521: 73-80.

1. Weigel C, Messer W*, Preiss S, Welzeck M, Morigen, E Boye. The sequence requirements for a functional Escherichia coli replication origin are different for the chromosome and a minichromosome, Mol Microbiol, 2001, 140(2): 498-507.


教研论文:

20.单冉东,刘艳,莫日根,冯虎元,李宗芸,孟庆繁,翁庆北,滕利荣. 全国大学生生命科学创新创业大赛实践的分析与研究.高校生物学教学研究(电子版)11(2):46-492021.

19.王彦凤, 王志钢, 王潇, 苑琳, 郝慧芳, 莫日根*. 基于综合素质培养的微生物实验教学改革探索. 实验室科学, 236):162-1652020.

18.莫日根,邢万金,范丽菲,哈达,哈斯阿古拉. 科学史引导的分子生物学教学架构和实践. 生物学杂志,33(5):112-,2016.

17.邢万金,莫日根*. 在遗传学课堂教学中培养本科生科研素质. 遗传,38():1-9,2016.

16.范丽菲,哈达,邢万金,莫日根. 问题导向的分子生物学教学改革与实践. 高校生物学教学研究(电子版),6(2):37-41,2016. 

15.林晓飞,征荣,莫日根*. 本科植物细胞与基因工程研究型实验课程的构建与实践. 遗传,37(4):402-6,2015.

14.邢万金,莫日根*. 遗传学教学中在细胞和分子水平上理解等位基因的显性与隐性. 遗传,37(1):98-108,2015.

13.莫日根,邢万金,王志钢,阿拉坦高勒,哈斯阿古拉,苑琳,侯鑫,苏慧敏,张彦桃,王郑,范丽菲. 本科生物技术综合性超大实验课程的架构与建设. 生物学杂志,31(3):104-107,2014.

12.刘鹏霞,王迎春,王潇,莫日根*. 以基地建设促进生命科学与技术创新人才培养. 高校生物学教学研究(电子版),4(4):13-152014.

11.邢万金,莫日根*. 小鼠毛色遗传的控制机制及其在遗传学教学中的作用. 遗传,36(10):1062-1068,2014。

10.邢万金,莫日根*,苏慧敏.生物学教学中研究型教学方法与内容的探索.遗传,36(7):732-7382014.

9.莫日根,邢万金,哈斯阿古拉.基因是什么?分子遗传学教学中的体会和理解.生物学杂志,29(4):92-95,2012.

8. 莫日根,邢万金,王潇. 以高水平科学研究促进分子遗传学教学. 高校生物学教学研究(电子版)2(1):33-352012.

7. 邢万金,莫日根,苏慧敏. 教好一门课,而不仅仅是讲好一本书:浅议遗传学教学改革. 生物学杂志,1(2)10-132012.

6. 邢万金,莫日根,苏慧敏. 遗传学教学内容中与其它课程重叠部分内容的处理. 高校生物学教学研究(电子版)1(2)10-132012.

5.杨贵生,王迎春,曹瑞,莫日根. 生物学野外综合实习基地的建设及对外开放实习的实践与探索. 高校生物学教学研究(电子版) 3(1):43-462012.

4.王迎春,莫日根,王潇.生命科学本科科研训练体系的建设与实践. 高校生物学教学研究(电子版),1(1):13-15,2011.

3.邢万金莫日根,苏慧敏,扈廷茂.遗传学双语教学改革的实践与体会. 生物学杂志,4-62011.

2.邢万金,莫日根*,阿拉坦高勒,苏慧敏. 以遗传信息为主线的遗传学教学架构及与其它课程的衔接. 遗传,33(6):661-6642011.

1. 莫日根,曹瑞.植物分子生物学英语教学实践与研究.理科高等教育,2000.

*示通讯作者或并列第一作者

 

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